I 100%'d Plague Inc. It Destroyed Me.

Seanie Dew

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The video chronicles the creator’s obsessive quest to earn every single achievement in Plague Inc., turning what began as casual curiosity into an all-consuming odyssey. Early on, he revisits the basics—naming pathogens, selecting transmission traits, and balancing lethality against stealth—only to realize that the game’s later scenarios demand far more nuanced micromanagement. Each new pathogen type forces him to rethink build orders, spore bursts, and symptom cascades, all while racing the in-game cure progress bar.

Midway through, the tone shifts from playful experimentation to calculated optimization. The creator dissects DNA routing, country-specific vulnerabilities, and the math behind infectivity curves. Fast forward through dozens of failed runs, and his desk is littered with handwritten flowcharts tracking when to devolve symptoms, when to trigger full lethality, and how to exploit climate modifiers. His commentary reveals a mixture of frustration and fascination as late-game achievements—like eradicating humanity without ever being detected—require perfect RNG and surgical timing.

The final stretch becomes a psychological grind. Speed-run achievements demand sub-real-time micromanagement, while custom scenarios introduce wildcard factors such as anti-vax campaigns or artificial intelligence defenses. Sleep schedules collapse, and the video’s edits toggle between caffeine-fueled strategizing and exhausted face-palming. Minor misclicks invalidate 45-minute runs, amplifying the tension and highlighting Plague Inc.’s unforgiving design.

When the last achievement finally unlocks, the celebration feels hollow. The creator reflects on hundreds of hours spent parsing spreadsheets, memorizing symptom trees, and brute-forcing RNG seeds. Though he now owns the coveted 100% completion badge, he questions whether the mental fatigue, skewed work-life balance, and creeping pandemic paranoia were worth it. The conclusion lands as both a cautionary tale and a tribute to the magnetic pull of mastery: Plague Inc. will reward persistence, but chasing absolute perfection can leave even the most dedicated player utterly drained.

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